Key result
Pharmacological agents such as quinidine, isoproterenol, and Ito blockers are reviewed for their potential beneficial role and mechanisms of action in the management of Brugada syndrome.
Why the study?
What is the role and mechanism of pharmacological agents in the management of Brugada syndrome?
What is the role and mechanism of pharmacological agents in the management of Brugada syndrome?
This review summarizes the potential mechanisms and clinical utility of pharmacological agents like quinidine and isoproterenol in managing Brugada syndrome, particularly as adjuncts or alternatives to implantable cardioverter-defibrillators.
May support adjunctive quinidine or isoproterenol use in Brugada syndrome; leaves open need for randomized trials.
Sudden cardiac death in healthy individuals with structurally normal hearts and a characteristic morphology of the QRS complex resembling a right bundle branch block with elevation of the ST segment in V1 to V3 is known as Brugada syndrome (BrS). Although placement of an implantable cardioverter-defibrillator is considered the only effective therapy for symptomatic patients, some authors have repeatedly reported a beneficial effect of quinidine and isoproterenol in patients with BrS. Also, isolated case reports on the usefulness of cilostazol, sotalol, and mexiletine have been described. The present article reviews the mechanisms by which these drugs may act and their role in the pharmacotherapy of BrS. Other possible agents, mainly Ito blockers, are also reviewed.
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Márquez et al. (2005) conducted a review in Brugada syndrome. Pharmacotherapy (quinidine, isoproterenol, cilostazol, sotalol, mexiletine, Ito blockers) was evaluated. Pharmacological agents such as quinidine, isoproterenol, and Ito blockers are reviewed for their potential beneficial role and mechanisms of action in the management of Brugada syndrome.
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