Why the study?
Sex differences exist in the pathophysiology of aortic valve calcification in aortic stenosis, but the underlying molecular and cellular mechanisms have not been elucidated.
Does the aldosterone/mineralocorticoid receptor pathway differentially affect valve interstitial cell activation, fibrosis, and calcification in men versus women with aortic stenosis?
Does the aldosterone/mineralocorticoid receptor pathway differentially affect valve interstitial cell activation, fibrosis, and calcification in men versus women with aortic stenosis?
The aldosterone/mineralocorticoid receptor pathway drives sex-specific pathological changes in aortic stenosis, promoting calcification in men and fibrosis in women, which can be blocked by MR antagonism.
No takes yet. Share an insight, caveat, or question.
Sex-specific aldosterone effects on VICs remain hypothesis-generating; human studies needed before considering sex-tailored MR antagonism in aortic stenosis.
Matilla et al. (2022) studied this question.
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