Key result
Obesity-associated genetic variants influence weight loss and metabolic outcomes after bariatric surgery.
Why the study?
Metabolic and bariatric surgery effectively treats obesity and related comorbidities, but individual responses vary, warranting examination of how genetic variants influence outcomes.
Do genetic variants associated with obesity influence post-surgery weight loss and metabolic outcomes in morbidly obese patients undergoing metabolic and bariatric surgery?
Systematic Review
Do genetic variants associated with obesity influence post-surgery weight loss and metabolic outcomes in morbidly obese patients undergoing metabolic and bariatric surgery?
Genetic variants associated with obesity may influence weight loss and metabolic outcomes following metabolic and bariatric surgery, highlighting a potential role for personalized treatment plans.
May inform genetic-informed counseling for bariatric surgery candidates; extends obesity genetics research to postoperative outcomes.
Metabolic and bariatric surgery (MBS) effectively treats obesity and related comorbidities, though individual responses vary. This systematic review examines how genetic variants influence MBS outcomes in morbidly obese patients. A comprehensive search in PubMed, Embase, Medline, and the Cochrane Library identified 1572 studies, with 52 meeting the inclusion criteria. Two reviewers independently filtered and selected studies, including relevant cross-references. Research focused on polymorphisms in genes such as UCP2, UCP3, 5-HT2C, MC4R, FKBP5, FTO, CAT haplotypes, LYPAL-1, PTEN, FABP-2, CNR1, LEP656, LEP223, GLP-1R, APOA-1, APOE, ADIPOQ, IL-6, PGC1a, TM6SF2, MBOAT7, PNPLA3, TCF7L2, ESR1, GHSR, GHRL, CD40L, DIO2, ACSL5, CG, TAS2R38, CD36, OBPIIa, NPY, BDNF, CLOCK, and CAMKK2. Most studies explored associations with post-surgery weight loss, while some examined metabolic, cardiovascular, taste, and eating behavior effects as well. Understanding the role of genetic factors in weight loss and metabolic outcomes post-MBS can help tailor personalized treatment plans for improved efficacy and long-term success. Further research with larger sample sizes and extended follow-up is needed to clarify the effects of many genetic variants on MBS outcomes in morbidly obese patients.
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Zafirovska et al. (2024) conducted a systematic review in Morbid obesity. Genetic variants associated with obesity was evaluated on Post-surgery weight loss, metabolic, cardiovascular, taste, and eating behavior effects. Genetic variants associated with obesity influence post-surgery weight loss and metabolic outcomes in morbidly obese patients undergoing metabolic and bariatric surgery.
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