Key result
Mice with a myoferlin null allele have smaller muscles lacking large diameter myofibers and display a dystrophic phenotype with impaired regeneration compared to wild-type controls.
Population
Myoferlin null mice and myoblasts
Comparison
Myoferlin gene knockout (null allele) vs Wild-type controls
Design
Preclinical
Authors
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Does not support clinical translation; leaves open myoferlin's role in human muscle disease.
Myoferlin is required for the maturation of myotubes and the formation of large myotubes during muscle growth and regeneration.
Doherty et al. (2005) studied Muscle growth and regeneration. Myoferlin null allele vs. Wild-type controls was evaluated on Muscle size, myofiber diameter, and regeneration capability. Mice with a myoferlin null allele have smaller muscles lacking large diameter myofibers and display a dystrophic phenotype with impaired regeneration compared to wild-type controls.
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