What question did this study set out to answer?

To determine the incidence, contributing pathogenetic mechanisms, and clinical predictors of adverse outcomes in hospitalized elderly patients who develop treatment-related acute renal failure.

February 1, 2000Nephrology Dialysis TransplantationOpen Access

Treatment-related acute renal failure in the elderly: a hospital-based prospective study

View Full Paper

Ask AI

Bookmark

Authors

HKHarbir Singh KohliPost Graduate Institute of Medical Education and Research MBMadhu BhaskaranRMIT University TMThangamani MuthukumarCornell University

Discussion

Member takes

Implication

Prospective cohort study observes treatment-related acute renal failure in hospitalized elderly individuals, indicating sepsis, hypotension, and oliguria predict poor clinical outcomes.

Key Points

To determine the incidence, contributing pathogenetic mechanisms, and clinical predictors of adverse outcomes in hospitalized elderly patients who develop treatment-related acute renal failure.
Conducted a prospective cohort screening of all elderly patients (>60 years) admitted over a 12-month period across their entire hospital stay (N=4,176 elderly out of 31,860 total admissions).
Evaluated precipitating clinical interventions, dialytic needs, and renal recovery rates, employing logistic regression analysis to identify independent predictors of patient mortality.
Treatment-related acute renal failure developed in 1.4% of elderly patients (n=59/4,176), precipitated primarily by nephrotoxic drugs (66.0%), hypoperfusion (45.7%), sepsis (45.7%), surgery (25.4%), and radiocontrast media (16.9%).
Radiocontrast administration (partial chi² 28.1, P<0.0001), surgery (partial chi² 14.89, P=0.001), and drugs (partial chi² 6.22, P=0.0126) each independently predicted the onset of renal failure.
In-hospital mortality was significantly higher in patients with acute renal failure than in those without (25.4% vs 12.5%; chi² 8.3, P=0.03), with sepsis (OR 43), oliguria (OR 64), and hypotension (OR 15) acting as independent predictors of death.

Cite This Study

Kohli et al. (2000) studied this question.

synapsesocial.com/papers/6a1eb80a217e80a52b9a6dff https://doi.org/10.1093/ndt/15.2.212

View Full Paper

Ask AI

Bookmark

Implication

Prospective cohort study observes treatment-related acute renal failure in hospitalized elderly individuals, indicating sepsis, hypotension, and oliguria predict poor clinical outcomes.

Treatment-related acute renal failure in the elderly: a hospital-based prospective study

Discussion

Member takes

Implication

Key Points

Cite This Study

Treatment-related acute renal failure in the elderly: a hospital-based prospective study

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider