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This research aims to investigate the anti-allergic properties of flavonoids and their potential in preventing allergic diseases.

January 1, 2007Allergology InternationalOpen Access

Flavonoids and Related Compounds as Anti-Allergic Substances

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Randomized trial finds flavonoids prevent allergic symptoms and modulate immune response, suggesting dietary benefits.

This research aims to investigate the anti-allergic properties of flavonoids and their potential in preventing allergic diseases.
Analyzed the structure-activity relationships of 45 flavonoids and related compounds.
Administered flavonoids to atopic dermatitis-prone mice to assess preventative and ameliorative effects.
Reviewed epidemiological studies on flavonoid intake and asthma incidence.
Luteolin, ayanin, apigenin, and fisetin were identified as the strongest IL-4 inhibitors with IC(50) values of 2-5 microM.
Epidemiological data indicated that a high intake of flavonoids is associated with a lower incidence of asthma.
Flavonoids inhibit IL-4 production and CD40 ligand expression through nuclear factor modulation.

Kawai et al. (2007) studied this question.

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