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Cellular study demonstrates that calnexin deficiency shifts cellular metabolism toward glycolysis and alters organelle contact, indicating its essential role in maintaining metabolic balance.
was available for mitochondria, a key determinant for mitochondrial bioenergetics. Calnexin-deficient cells compensated for the loss of this function by partially shifting energy generation to the glycolytic pathway. These cells also showed closer apposition between the ER and mitochondria. Calnexin therefore controls the cellular energy balance between oxidative phosphorylation and glycolysis.
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Gutiérrez et al. (2020) studied this question.
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