Adverse Bioenergetic Consequences of Na + -Ca 2+ Exchanger–Mediated Ca 2+ Influx in Cardiac Myocytes
Population
Guinea-pig cardiac myocytes
Design
Preclinical
Authors
Discussion
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Member takes
Implication
May implicate NCX in HF energy deficits; hypothesis-generating in animal models, needs human validation.
Structured PICO
P
Population
Guinea-pig cardiac myocytes
I
Intervention
Varying Ca2+ influx via L-type Ca2+ channels (I(Ca,L)) or the Na+-Ca2+ exchanger (NCX)
O
Outcome
Cytosolic and mitochondrial Ca2+ levels, efficiency of mitochondrial Ca2+ uptake, and stimulation of Ca2+-sensitive dehydrogenasessurrogate
Increased NCX-mediated Ca2+ influx impairs mitochondrial Ca2+ uptake and bioenergetic feedback, suggesting a mechanism for energy starvation in failing hearts.
Cite This Study
Kohlhaas et al. (2010) studied this question.