What question did this study set out to answer?

This study aims to explore the effects of antiadrenergic drugs on catecholamine turnover in both normotensive and hypertensive individuals.

October 1, 1968Journal of Clinical InvestigationOpen Access

Catecholamine turnover in normotensive and hypertensive man: effects of antiadrenergic drugs

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Why the study?

Does catecholamine turnover differ between normotensive individuals and patients with essential hypertension, and how do antiadrenergic drugs affect it?

Population

23 hospitalized subjects: 5 normal volunteers, 10 patients with uncomplicated essential hypertension, and 8…

Comparison

Intravenous infusion of tritium-labeled… vs Normotensive volunteers compared to patients…

Design

Cohort

Follow-up

3-7 days

Authors

VDVincent DeQuattroUniversity of California, San Francisco ASAlbert SjoerdsmaUniversity of Southern California

Discussion

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Implication

Similar norepinephrine half-lives should not alter hypertension management; supports no gross metabolic abnormality but remains hypothesis-generating.

Key Points

This study aims to explore the effects of antiadrenergic drugs on catecholamine turnover in both normotensive and hypertensive individuals.
Intravenous administration of tritium-labeled dopa to subjects.
Assessment of urinary and cardiac norepinephrine specific activity and turnover rates.
Treatment evaluation through alpha-methyltyrosine, reserpine, and pargyline hydrochloride.
The half-time of labeled urinary norepinephrine was about 8 hours and 11-16 hours for VMA in normal subjects.
Hypertensive patients showed no significant differences in catecholamine turnover compared to normal individuals.
In surgery patients, norepinephrine half-life was 5 hours with a correlation to urinary decline.

Structured PICO

Does catecholamine turnover differ between normotensive individuals and patients with essential hypertension, and how do antiadrenergic drugs affect it?

Population

23 hospitalized subjects: 5 normal volunteers (aged 19-35 yr, 2 males/3 females), 10 patients with uncomplicated essential hypertension (aged 32-54 yr, 4 males/6 females), and 8 patients with congenital or rheumatic heart disease undergoing corrective cardiac surgery (aged 16-42 yr, 4 males/4 females).

Intervention

Intravenous infusion of tritium-labeled 3,4-dihydroxyphenylalanine (dopa-3H) at a constant rate for 30 min. A subgroup of hypertensive patients also received antiadrenergic drugs (alpha-methyltyrosine, reserpine, or pargyline hydrochloride).

Comparator

Normotensive volunteers compared to patients with essential hypertension; and pre-drug control state compared to post-drug state in treated patients.

Outcome

Apparent turnover rates (half-life) of norepinephrine and vanillylmandelic acid (VMA) estimated from the exponential decline in specific activity in fractional urine collections and cardiac biopsies.surrogate

Catecholamine turnover rates are similar in normotensive and essential hypertensive subjects, suggesting no gross abnormality in overall norepinephrine metabolism in essential hypertension.

Limitations

Possible minor differences in turnover rates of dopamine and VMA would require evaluation of a much larger series of cases.

Cite This Study

DeQuattro et al. (1968) studied this question.

synapsesocial.com/papers/6a1ebc5cbf2a5d44faaf404f https://doi.org/10.1172/jci105920

Topics

Hypertension management

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Implication

Similar norepinephrine half-lives should not alter hypertension management; supports no gross metabolic abnormality but remains hypothesis-generating.

Catecholamine turnover in normotensive and hypertensive man: effects of antiadrenergic drugs

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Topics

Catecholamine turnover in normotensive and hypertensive man: effects of antiadrenergic drugs

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider