What question did this study set out to answer?

To determine the developmental trajectory of neonatal B-1a cells and assess their ability to undergo neoplastic transformation into mantle cell lymphoma-like disease during aging.

June 13, 2018The Journal of ImmunologyOpen Access

Early Generated B-1–Derived B Cells Have the Capacity To Progress To Become Mantle Cell Lymphoma–like Neoplasia in Aged Mice

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Authors

KHKyoko HayakawaFox Chase Cancer Center AFAnthony M. Formica YNYuka Nakao

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Implication

Preclinical study reveals early-generated B-1a cells can develop into mantle cell lymphoma-like tumors in aged mice, indicating an origin for late-life B cell malignancies.

Key Points

To determine the developmental trajectory of neonatal B-1a cells and assess their ability to undergo neoplastic transformation into mantle cell lymphoma-like disease during aging.
Tracked the development, splenic maturation, and tissue distribution of neonatal B1a cells using an autoreactive antiphosphatidylcholine knock-in mouse model (VH11t).
Monitored aged C.B17 mice expressing an antithymocyte/Thy-1 autoreactivity (ATA) B cell receptor transgene alone or alongside an Eμ-cyclin D1 transgene to evaluate tumor formation.
Neonatal B-1a cells matured in the spleen and populated the intestinal tract and mesenteric lymph nodes, with a subset progressing to monoclonal B cell lymphocytosis in aged mice.
Mice bearing the ATA BCR transgene exhibited elevated peripheral blood B cells, splenomegaly, and mesenteric lymph node hyperplasia accompanied by elevated CD11b, IL-10, and activated Stat3.
Co-expression of cyclin D1 in ATA mice accelerated neoplastic progression to diffuse, aggressive lymphomas characterized by IgMhiIgDloCD5+CD23-CD43+ cells resembling human mantle cell lymphoma.

Cite This Study

Hayakawa et al. (2018) studied this question.

synapsesocial.com/papers/6a1ebd2d5dae381e029a8878 https://doi.org/10.4049/jimmunol.1800400

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Implication

Preclinical study reveals early-generated B-1a cells can develop into mantle cell lymphoma-like tumors in aged mice, indicating an origin for late-life B cell malignancies.

Early Generated B-1–Derived B Cells Have the Capacity To Progress To Become Mantle Cell Lymphoma–like Neoplasia in Aged Mice

Discussion

Member takes

Implication

Key Points

Cite This Study

Early Generated B-1–Derived B Cells Have the Capacity To Progress To Become Mantle Cell Lymphoma–like Neoplasia in Aged Mice

Discussion

Member takes

Implication

Key Points

Cite This Study

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