What does this research mean for the field?

Rivaroxaban is more effective than standard aspirin therapy for preventing and treating lower extremity deep vein thrombosis after radiofrequency catheter ablation, reducing the incidence of non-occluded thrombus without increasing bleeding risk. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

June 22, 2016Scientific ReportsOpen Access

Prevention and Treatment of Lower Limb Deep Vein Thrombosis after Radiofrequency Catheter Ablation: Results of a Prospective active controlled Study

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Why the study?

Does rivaroxaban reduce the occurrence of lower extremity deep vein thrombosis compared to aspirin in patients undergoing radiofrequency catheter ablation?

Structured PICO

Does rivaroxaban reduce the occurrence of lower extremity deep vein thrombosis compared to aspirin in patients undergoing radiofrequency catheter ablation?

Population

176 Chinese adults (mean age 57.6, 47.15% male) with rapid ventricular tachyarrhythmia undergoing radiofrequency catheter ablation (RFCA). Key inclusion: 18 years or older, no symptoms of pulmonary embolism, no prior vitamin-K antagonist or other anticoagulant, ≤36 hours of treatment with unfractionated heparin or low-molecular-weight heparin.

Intervention

Rivaroxaban 10 mg oral once daily for 14 days, beginning 2-3 hours post-operation.

Comparator

Aspirin 100 mg oral once daily for 3 months, beginning 2-3 hours post-operation.

Outcome

Composite of lower extremity deep vein thrombosis (LDVT) occurrence, change in diameter of femoral veins, and safety outcomes (major or minor bleeding events).composite

Rivaroxaban 10 mg daily for 14 days post-radiofrequency catheter ablation significantly reduces the incidence of asymptomatic non-occluded femoral vein thrombosis compared to standard aspirin therapy, without increasing bleeding risk.

Limitations

Single center
Smaller sample size

Discussion

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Implication

Rivaroxaban was associated with fewer non-occluded thrombi post-ablation; hypothesis-generating and should not yet change practice.

Cite This Study

Li et al. (2016) studied this question.

synapsesocial.com/papers/6a1ec134989adebfe89a8b52 https://doi.org/10.1038/srep28439

Topics

AF ablation outcomes

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Prevention and Treatment of Lower Limb Deep Vein Thrombosis after Radiofrequency Catheter Ablation: Results of a Prospective active controlled Study

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Topics

Prevention and Treatment of Lower Limb Deep Vein Thrombosis after Radiofrequency Catheter Ablation: Results of a Prospective active controlled Study

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider