What question did this study set out to answer?

To correlate imaging boundaries from computerized tomography (CT) and magnetic resonance imaging (MRI) with histological findings from serial stereotaxic biopsies in untreated intracranial glial neoplasms.

June 1, 1987Journal of neurosurgery

Imaging-based stereotaxic serial biopsies in untreated intracranial glial neoplasms

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Authors

PKPatrick J. KellyThe University of Sydney CDC. Daumas‐DuportCentre Hospitalier Régional et Universitaire de Nancy DKDavid B. KispertMidwest Orthopaedic Research Foundation

Discussion

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Overview

Observational imaging study reveals tumor cell infiltration extends throughout T2-prolonged areas in glial neoplasms, indicating standard CT underestimates tumor boundaries.

Key Points

To correlate imaging boundaries from computerized tomography (CT) and magnetic resonance imaging (MRI) with histological findings from serial stereotaxic biopsies in untreated intracranial glial neoplasms.
Assessed 40 patients with previously untreated intracranial glial neoplasms using CT- and MRI-assisted stereotaxic serial biopsies.
Reconstructed tumor volumes across imaging modalities, analyzing CT contrast enhancement and hypodensity alongside MRI T1 and T2 prolongation.
Performed histological analysis across 195 stereotaxic biopsy specimens collected from defined imaging zones.
Tumor volumes determined by T2-weighted MRI scans were consistently larger than those defined by CT low-attenuation or contrast enhancement.
Histology demonstrated that CT contrast enhancement represented solid tumor parenchyma, hypodensity indicated isolated tumor cell infiltration or edema, and isolated tumor cell infiltration extended at least as far as T2 prolongation on MRI.

Cite This Study

Kelly et al. (1987) studied this question.

synapsesocial.com/papers/6a1ec134bf2a5d44faaf4656 https://doi.org/10.3171/jns.1987.66.6.0865

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June 1, 1987Journal of neurosurgery

Imaging-based stereotaxic serial biopsies in untreated intracranial glial neoplasms

View Full Paper

Ask AI

Bookmark

Authors

PKPatrick J. KellyThe University of Sydney CDC. Daumas‐DuportCentre Hospitalier Régional et Universitaire de Nancy DKDavid B. KispertMidwest Orthopaedic Research Foundation

Discussion

Member takes

Overview

Observational imaging study reveals tumor cell infiltration extends throughout T2-prolonged areas in glial neoplasms, indicating standard CT underestimates tumor boundaries.

Key Points

To correlate imaging boundaries from computerized tomography (CT) and magnetic resonance imaging (MRI) with histological findings from serial stereotaxic biopsies in untreated intracranial glial neoplasms.
Assessed 40 patients with previously untreated intracranial glial neoplasms using CT- and MRI-assisted stereotaxic serial biopsies.
Reconstructed tumor volumes across imaging modalities, analyzing CT contrast enhancement and hypodensity alongside MRI T1 and T2 prolongation.
Performed histological analysis across 195 stereotaxic biopsy specimens collected from defined imaging zones.
Tumor volumes determined by T2-weighted MRI scans were consistently larger than those defined by CT low-attenuation or contrast enhancement.
Histology demonstrated that CT contrast enhancement represented solid tumor parenchyma, hypodensity indicated isolated tumor cell infiltration or edema, and isolated tumor cell infiltration extended at least as far as T2 prolongation on MRI.

Cite This Study

Kelly et al. (1987) studied this question.

synapsesocial.com/papers/6a1ec134bf2a5d44faaf4656 https://doi.org/10.3171/jns.1987.66.6.0865

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