Key result
Complete pulmonary vein isolation in a simulated human atrial model led to a decrease in both the amplitude and the area of the P-wave, with differences most pronounced in the posterior side of the torso.
Why the study?
Defining parameters able to predict successful pulmonary vein isolation and detect reconnections can assist clinicians in treating atrial fibrillation patients.
Does simulated pulmonary vein isolation reduce P-wave amplitude and area in a human atrial computer model?
Does simulated pulmonary vein isolation reduce P-wave amplitude and area in a human atrial computer model?
Absolute Event Rate: 1.0832% vs 1.3517%
Computational modeling demonstrates that pulmonary vein isolation acutely reduces P-wave amplitude and area, with the most pronounced changes detectable on posterior torso leads.
Pulmonary vein (PV) plays an important role in atrial fibrillation (AF) initiation, progression, and stability. Successful PV isolation (PVI), either by radiofrequency catheter or Cryoballoon ablation, may terminate AF and prevent its recurrence. Whereas, incomplete PV isolation or reconnection of isolated PVs underlies mechanisms of AF recurrence. Hence, defining parameters able to predict a successful PVI and detect reconnections can assist clinicians in treatment of AF patients. Here, we developed a highly detailed human atrial model to simulate PVI and its acute effect on the P-wave morphology. Afterwards, the simulation results were compared and validated by recorded ECGs from patients before and after PVI procedure. In both simulation data and clinical recordings, we observed morphological changes in Pwave after PVI. More importantly our simulation helped us to find electrode positions, in which the differences in P-wave morphology before and after PVI were more pronounced.
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Gharaviri et al. (2018) studied Atrial fibrillation. Pulmonary vein isolation (PVI) vs. Control simulation (no ablation lines) / Pre-ablation was evaluated on Averaged P-wave area. Complete pulmonary vein isolation in a simulated human atrial model led to a decrease in both the amplitude and the area of the P-wave, with differences most pronounced in the posterior side of the torso.
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