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September 27, 2023International Journal of Clinical PharmacyOpen Access

Guideline adherence for cardiometabolic monitoring of patients prescribed antipsychotic medications in primary care: a retrospective observational study

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Key result

Only ~20% of patients prescribed chronic antipsychotics receive standard yearly cardiometabolic monitoring.

  • n=497

Why the study?

Antipsychotics carry significant cardiometabolic adverse event profiles, but adherence to routine guideline-recommended monitoring in primary care is known to be suboptimal.

Are patients prescribed chronic antipsychotic therapy in primary care receiving adequate cardiometabolic monitoring according to guidelines?

Population

497 patients with mental disorders prescribed antipsychotics at two general practices in England

Comparison

Patient-related factors and drug characteristics predicting cardiometabolic monitoring

Design

Retrospective observational study

Authors

RARuba Saleh Azfr AliUmm al-Qura UniversityZJZahraa JalalUniversity of BirminghamJJJaspal JohalDudley Group NHS Foundation Trust

Discussion

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Implication

Suboptimal monitoring in primary care may warrant quality improvement; leaves open whether interventions boost guideline adherence in antipsychotic users.

Study Design

Type

Observational (n=497)

Multicenter

Yes

Structured PICO

Are patients prescribed chronic antipsychotic therapy in primary care receiving adequate cardiometabolic monitoring according to guidelines?

P
Population
497 adults with mental disorders prescribed chronic antipsychotic therapy for at least 12 months, evaluated retrospectively over a 3-year period in UK primary care.
E
Exposure
Chronic antipsychotic therapy (prescribed for at least 12 months)
O
Outcome
Proportion of patients with evidence of monitoring for cardiometabolic parameters (body composition, anthropometrics, lipids, glucose outcomes)

Routine cardiometabolic monitoring for primary care patients on antipsychotics is infrequent and fails to meet guideline recommendations, particularly for glucose and comprehensive lipid profiles.

Limitations

  • Retrospective design relying on the accuracy of data recording and coding
  • Limited generalizability due to the small number of participating sites (two general practices)
  • Limited number of positive observations for some variables (e.g., WC and HbA1c) preventing modeling

Cite This Study

Ali et al. (2023) conducted an observational in Mental disorders prescribed antipsychotics (n=497). Chronic antipsychotic therapy was evaluated on Proportion of patients with evidence of monitoring for cardiometabolic parameters at least once yearly. Routine cardiometabolic monitoring for patients prescribed antipsychotics was suboptimal, with standard yearly monitoring achieved in only approximately 20% of patients.

synapsesocial.com/papers/6a1ec33d544bdf605faf4020https://doi.org/10.1007/s11096-023-01642-5
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardiovascular risk screening of patients with serious mental illness or use of antipsychotics in family practice2020 · 15 citations
  2. 2Prescribing pattern of antipsychotic drugs during the years 1996–2010: a population‐based database study in Europe with a focus on torsadogenic drugs2016 · 30 citations
  3. 3The gap in life expectancy from preventable physical illness in psychiatric patients in Western Australia: retrospective analysis of population based registers2013 · 841 citations
  4. 4Lipid profile screening in second-generation antipsychotic users: the gap between policy and practice2010 · 2 citations
  5. 5Disparities in Screening and Treatment of Cardiovascular Diseases in Patients With Mental Disorders Across the World: Systematic Review and Meta-Analysis of 47 Observational Studies2021 · 144 citations