Mutations of MAP2K1 are frequent in pediatric-type follicular lymphoma and result in ERK pathway activation

J Schmidt; Joan E. Ramis-Zaldivar; Ferran Nadeu; Blanca González‐Farré; Alba Navarro; Caoimhe Egan; Ivonne A. Montes‐Mojarro; Teresa Marafioti; José Cabeçadas; Jon van der Walt; Stefan Dojcinov; Andreas Rosenwald; German Ott; Irina Bonzheim; Falko Fend; Elı́as Campo; Elaine S. Jaffe; Itziar Salaverría; Leticia Quintanilla‐Martínez

doi:10.1182/blood-2017-03-776278

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Abstract

Key Points TNFRSF14 and MAP2K1 mutations are frequent in PTFL but do not occur together in the majority of cases. MAP2K1 mutations lead to activation of the downstream target phosphorylated extracellular signal-regulated kinase.

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Schmidt et al. (2017) studied this question.

synapsesocial.com/papers/6a1ec41fbf2a5d44faaf4b05 https://doi.org/10.1182/blood-2017-03-776278

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Mutations of MAP2K1 are frequent in pediatric-type follicular lymphoma and result in ERK pathway activation

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Abstract

Discussion

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Mutations of MAP2K1 are frequent in pediatric-type follicular lymphoma and result in ERK pathway activation

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Abstract

Discussion

Cite This Study

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