Key result
Female sex is associated with distinct cerebrovascular hemodynamic profiles, including more efficient dynamic cerebral autoregulation, which may influence age- and hormone-dependent vulnerabilities to stroke.
This review emphasizes the unmet need to understand sex-specific mechanisms in cerebrovascular hemodynamics to develop more effective therapeutic and preventive strategies for women.
Sex and gender, as biological and social factors, significantly influence health outcomes. Among the biological factors, sex differences in vascular physiology may be one specific mechanism contributing to the observed differences in clinical presentation, response to treatment, and clinical outcomes in several vascular disorders. This review focuses on the cerebrovascular bed and summarizes the existing literature on sex differences in cerebrovascular hemodynamics to highlight the knowledge deficit that exists in this domain. The available evidence is used to generate mechanistically plausible and testable hypotheses to underscore the unmet need in understanding sex-specific mechanisms as targets for more effective therapeutic and preventive strategies.
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Duque et al. (2017) conducted a review in Cerebrovascular disease. Female sex vs. Male sex was evaluated. Female sex is associated with distinct cerebrovascular hemodynamic profiles, including more efficient dynamic cerebral autoregulation, which may influence age- and hormone-dependent vulnerabilities to stroke.
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