Key result
Panic disorder and generalized anxiety disorder will be prospectively evaluated for their prevalence, incidence, and prognostic implications in a planned longitudinal cohort of 3,610 patients with coronary artery disease.
Why the study?
Anxiety is associated with poorer prognosis in CAD, making the epidemiology and prognostic implications of severe, chronic anxiety disorders such as GAD and PD of key clinical importance.
Does the presence of panic disorder or generalized anxiety disorder increase adverse cardiac events and worsen health behaviors in patients with coronary artery disease?
Cohort (n=3,610)
Yes
Does the presence of panic disorder or generalized anxiety disorder increase adverse cardiac events and worsen health behaviors in patients with coronary artery disease?
This study protocol describes a prospective cohort study designed to evaluate the prevalence, incidence, and prognostic impact of panic disorder and generalized anxiety disorder in patients following coronary revascularization.
Anxiety disorders' prognostic role in CAD remains unclear; this cohort will extend prospective data on prevalence, incidence, and outcomes.
BACKGROUND: Anxiety is associated with poorer prognosis in patients with coronary artery disease (CAD). Due to their severity and chronic course, anxiety disorders, particularly generalized anxiety disorder (GAD) and panic disorder (PD), are of considerable interest and clinical importance in this population. This study has two main objectives: (1) to estimate the prevalence and incidence of GAD and PD in patients with CAD over a 2-year period and (2) to prospectively assess the association between PD or GAD and adverse cardiac events, treatment adherence, CAD-related health behaviors, quality of life and psychological distress. DESIGN/METHOD: This is a longitudinal cohort study in which 3610 participants will be recruited following a CAD-related revascularization procedure. They will complete an interview and questionnaires at 5 time points over a 2-year period (baseline and follow-ups after 3, 6, 12 and 24 months). The presence of PD or GAD, adherence to recommended treatments, health behaviors, quality of life and psychological distress will be assessed at each time point. Data regarding mortality and adverse cardiac events will be collected with a combination of interviews and review of medical files. DISCUSSION: This study will provide essential information on the prevalence and incidence of anxiety disorders in patients with CAD and on the consequences of these comorbidities. Such data is necessary in order to develop clear clinical recommendations for the management of PD and GAD in patients with CAD. This will help improve the prognosis of patients suffering from both conditions.
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Foldes‐Busque et al. (2021) conducted a cohort in Coronary artery disease (n=3,610). Panic disorder and generalized anxiety disorder vs. Patients without panic disorder or generalized anxiety disorder was evaluated on Prevalence and incidence of GAD and PD, and adverse cardiac events. Panic disorder and generalized anxiety disorder will be prospectively evaluated for their prevalence, incidence, and prognostic implications in a planned longitudinal cohort of 3,610 patients with coronary artery disease.
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