Key result
ACE inhibitors and angiotensin receptor blockers show significant potential as a novel integrated approach for treating various brain disorders, particularly psychiatric illnesses.
Why the study?
The renin-angiotensin system plays established roles in cardiovascular homeostasis, but its potential functions and therapeutic relevance in the brain and associated disorders have only been recognized more recently.
Do ACE inhibitors and ARBs provide therapeutic benefits in patients with psychiatric and neurodegenerative disorders?
Do ACE inhibitors and ARBs provide therapeutic benefits in patients with psychiatric and neurodegenerative disorders?
ACE inhibitors and ARBs may have therapeutic potential beyond cardiovascular disease for the treatment of psychiatric and neurodegenerative disorders.
Should not yet change practice for psychiatric or neurodegenerative disorders; leaves open the need for prospective trials of RAS modulation.
The renin-angiotensin system (RAS) plays essential roles in maintaining peripheral cardiovascular homeostasis, with its potential roles in the brain only being recognized more recently. Angiotensin-I-converting enzyme (ACE) is the main component of the RAS, and it has been implicated in various disorders of the brain. ACE and other RAS components, including the related enzyme ACE2, angiotensin peptides and their respective receptors, can participate in the pathological state, as well as with potential to contribute to neuroprotection and/or to complement existing treatments for psychiatric illness. In this narrative review, we aimed to identify the main studies describing the functions of the RAS and ACEs in the brain and their association with brain disorders. These include neurodegenerative disorders such as Parkinson's and Alzheimer's diseases, psychiatric illnesses such as schizophrenia, bipolar disorder, and depression. We also discuss the possible association of a functional polymorphism of the ACE gene with these brain diseases and the relevance of the neuroprotective and anti-inflammatory properties of ACE inhibitors (ACEis) and angiotensin receptor blockers (ARBs). Based on this, we conclude that there is significant potential value to the inclusion of ACEis and/or ARBs as a novel integrated approach for the treatment of various disorders of the brain, and particularly for psychiatric illness.
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Santiago et al. (2023) conducted a review in Psychiatric and neurodegenerative disorders. ACE inhibitors and angiotensin receptor blockers was evaluated. ACE inhibitors and angiotensin receptor blockers show significant potential as a novel integrated approach for treating various brain disorders, particularly psychiatric illnesses.
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