Key result
Administered ACTH significantly increased the aldosterone metabolic clearance rate and excretion of THAldo on the third day of treatment in healthy male volunteers.
Why the study?
Does administered ACTH alter aldosterone metabolism and secretion in healthy male volunteers?
Does administered ACTH alter aldosterone metabolism and secretion in healthy male volunteers?
ACTH administration increases aldosterone metabolic clearance and hepatic THAldo formation, suggesting its stimulatory effect on aldosterone secretion is more sustained than previously thought.
Answers are grounded in this paper and cite their sources.
May indicate more sustained ACTH effects on aldosterone than assumed; leaves open relevance in adrenal disorders.
To determine better the overall regulation of aldosterone by ACTH, the effect of administered ACTH on the aldosterone metabolic clearance rate (MCR), the excretion rates of tetrahydroaldosterone (THAldo), and the acid-labile conjugate (ALC) of aldosterone were studied in healthy male volunteers on a sodium intake in excess of 200 mEq/day. In 7 subjects, the aldosterone MCR increased significantly on the third day of ACTH treatment, as did the excretion of THAldo, but there was a decrease in the excretion of the ALC. One subject receiving ACTH for 6 days showed a steady increase in the aldosterone MCR on days 3 and 6 of treatment. In 2 of 3 subjects receiving ACTH treatment for 3-4 days, plasma aldosterone levels and plasma renin activity showed little change, whereas in 1 subject, both plasma aldosterone and plasma renin activity became suppressed. During ACTH administration there was a sustained increase in the excretion of THAldo, a metabolite formed in the liver, (in contrast to a decreasing excretion of the ALC which is made principally in the kidneys) which suggests that the increased aldosterone metabolism in response to ACTH occurred in the liver. Measurements made of the excretion of THAldo show that the ACTH stimulatory effect on aldosterone secretion may not be as transient as previously reported.
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Pratt et al. (1976) studied Healthy volunteers. ACTH was evaluated on Aldosterone metabolic clearance rate (MCR) and excretion rates of THAldo and ALC. Administered ACTH significantly increased the aldosterone metabolic clearance rate and excretion of THAldo on the third day of treatment in healthy male volunteers.
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