Key result
Moderate to severe obstructive sleep apnea was associated with impaired cardiac diastolic function, evidenced by a significantly lower E/A ratio (0.98 vs 1.08, P=0.0001) compared to mild OSA in elderly patients without cardiovascular disease.
Why the study?
To evaluate changes in cardiac structure and function and their risk factors in elderly patients with obstructive sleep apnea syndrome without cardiovascular complications.
Does moderate to severe obstructive sleep apnea impair cardiac diastolic function in elderly patients without pre-existing cardiovascular disease compared to mild OSA?
Cross-Sectional (n=82)
Yes
Does moderate to severe obstructive sleep apnea impair cardiac diastolic function in elderly patients without pre-existing cardiovascular disease compared to mild OSA?
Elderly patients with moderate to severe obstructive sleep apnea exhibit early signs of cardiac diastolic function impairment even in the absence of hypertension or other cardiovascular diseases.
OBJECTIVE: To evaluate the changes of cardiac structure and function and their risk factors in elderly patients with obstructive sleep apnea syndrome (OSA) without cardiovascular complications. METHODS: Eighty-two elderly OSA patients without cardiovascular disease admitted between January, 2015 and October, 2016 were enrolled in this study. According to their apnea-hypopnea index (AHI, calculated as the average number of episodes of apnoea and hypopnoea per hour of sleep), the patients were divided into mild OSA group (AHI < 15) and moderate to severe OSA group (AHI ≥ 15). The demographic data and the general clinical data were recorded and fasting blood samples were collected from the patients on the next morning following polysomnographic monitoring for blood cell analysis and biochemical examination. Echocardiography was performed within one week after overnight polysomnography, and the cardiac structure, cardiac function and biochemical indexes were compared between the two groups. CONCLUSIONS: Cardiac diastolic function impairment may occur in elderly patients with moderate or severe OSA who do not have hypertension or other cardiovascular diseases, and the severity of the impairment is positively correlated with AHI.
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Gao et al. (2020) conducted a cross-sectional in Obstructive sleep apnea syndrome (n=82). Moderate to severe obstructive sleep apnea (AHI ≥ 15) vs. Mild obstructive sleep apnea (AHI < 15) was evaluated on E/A ratio (early to late diastolic mitral flow velocity ratio) (p=0.0001). Moderate to severe obstructive sleep apnea was associated with impaired cardiac diastolic function, evidenced by a significantly lower E/A ratio (0.98 vs 1.08, P=0.0001) compared to mild OSA in elderly patients without cardiovascular disease.
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