Key result
Moderate-to-severe obstructive sleep apnea without hypertension was associated with impaired right ventricular function and increased wall thickness compared to BMI-matched controls (p<0.001).
Why the study?
Is moderate-to-severe obstructive sleep apnea without systemic hypertension associated with right ventricular structural and functional alterations compared to matched controls?
Observational (n=71)
Is moderate-to-severe obstructive sleep apnea without systemic hypertension associated with right ventricular structural and functional alterations compared to matched controls?
p-value: p=<0.001
Moderate-to-severe obstructive sleep apnea is associated with right ventricular dysfunction and structural changes independent of systemic hypertension, with the degree of dysfunction correlating directly with OSA severity.
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Supports RV evaluation in severe OSA without HTN; hypothesis-generating pending prospective outcome trials.
Tuğcu et al. (2009) conducted an observational in Obstructive sleep apnea syndrome without hypertension (n=71). Moderate-to-severe obstructive sleep apnea vs. Body mass index-matched healthy controls was evaluated on Right ventricular structural and functional cardiac alterations (p=<0.001). Moderate-to-severe obstructive sleep apnea without hypertension was associated with impaired right ventricular function and increased wall thickness compared to BMI-matched controls (p<0.001).
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