Key result
ACE inhibitors and calcium channel blockers were associated with a depression-provoking effect, with rate ratios of 1.29 (95% CI 1.08-1.56) and 1.31 (95% CI 1.14-1.51), respectively.
Why the study?
Do cardiovascular medications provoke depression in incident antidepressant users?
Observational (n=11,244)
Do cardiovascular medications provoke depression in incident antidepressant users?
Relative Risk: 1.29 (95% CI 1.08–1.56)
Prescription sequence symmetry analysis suggests that ACE inhibitors and calcium channel blockers may have a depression-provoking effect.
No takes yet. Share an insight, caveat, or question.
These associations should not alter prescribing; hypothesis-generating and requires prospective confirmation before clinical consideration.
Jesper Hallas (1996) conducted an observational in Depression (n=11,244). Angiotensin-converting enzyme (ACE) inhibitors and calcium channel blockers vs. Symmetrical distribution of prescription orders (starting antidepressant first) was evaluated on Depression-provoking effect (starting cardiovascular drug before antidepressant) (RR 1.29, 95% CI 1.08-1.56). ACE inhibitors and calcium channel blockers were associated with a depression-provoking effect, with rate ratios of 1.29 (95% CI 1.08-1.56) and 1.31 (95% CI 1.14-1.51), respectively.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: