Key result
Handheld ultrasound correlates closely with conventional ultrasound for abdominal organ measurements.
Why the study?
Abdominal ultrasound is key for diagnosing sinusoidal obstruction syndrome/veno-occlusive disease, but little data exist on the value of portable hand-held ultrasound devices in this setting.
Does portable hand-held ultrasound provide comparable measurements to conventional ultrasound in patients undergoing allogeneic HCT?
Observational (n=16)
Blinded operators
No
Does portable hand-held ultrasound provide comparable measurements to conventional ultrasound in patients undergoing allogeneic HCT?
Effect estimate: r = 0.912
p-value: p=<0.0001
Handheld ultrasound devices demonstrate excellent agreement with conventional ultrasound for assessing abdominal parameters, potentially facilitating SOS/VOD diagnosis in HCT patients.
Supports handheld ultrasound for bedside abdominal assessment in HCT patients; leaves open its diagnostic role for SOS/VOD pending prospective validation.
Abdominal ultrasound exams play a major role in the diagnosis of sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD). The development of portable hand-held ultrasound devices (HHUS) has been shown to facilitate the diagnosis of many diseases, but little data on the value of HHUS in the diagnosis of SOS/VOD are available. We performed a study aimed at validating portable ultrasound (US) devices in the setting of hematopoietic stem cell transplant (HCT). Sixteen evaluable patients undergoing allogeneic HCT were studied using conventional US and HHUS during the first 3 weeks after transplant. The results obtained demonstrate that there is a close correlation between conventional and handheld ultrasound examination in the measurement of the right hepatic lobe (r = 0.912, p < 0.0001), the left hepatic lobe (r = 0.843, p < 0.0001), the portal vein (PV) (r = 0.724, p < 0.0001), and the spleen (r = 0.983, p < 0.0001) based on Pearson’s correlation. The same data, analyzed through Lin’s concordance correlation coefficient, evidenced a substantial level of agreement in the comparison of the spleen and right hepatic lobe, while a lower grade of agreement in the measurement of the portal vein and left hepatic lobe. Moreover, there was good agreement between results obtained by the two types of ultrasound devices in assessing ascites (p < 0.0001), gallbladder thickening (p < 0.0001), and the direction of PV flow (p < 0.0001). HHUS device allows the study of HokUs-10 parameters with an excellent agreement with conventional US, and may contribute to SOS/VOD diagnosis.
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Duminuco et al. (2023) conducted an observational in Hematopoietic stem cell transplant (HCT) / SOS/VOD (n=16). Handheld ultrasound (HHUS) vs. Conventional ultrasound was evaluated on Correlation in measurement of the right hepatic lobe (r = 0.912, p=<0.0001). Handheld ultrasound demonstrated a close correlation with conventional ultrasound in measuring the right hepatic lobe (r = 0.912), left hepatic lobe (r = 0.843), portal vein (r = 0.724), and spleen (r = 0.983).
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