A Bibliometric Analysis of Chalcones with Antimicrobial Potential

ABSTRACT:Purpose: Chalcones are secondary metabolites that occur naturally in plants and cannot be synthesized in the human and animal body. Its structure is 1,3-diaryl-2-propen-1-one and is the precursor of flavonoids. It has many important activities such as antimicrobial, antidiabetic, antiviral, antifungal, anti-inflammatory, antituberculosis and antitumor. The aim of this study was to conduct first time a bibliometric analysis on chalcones and their antimicrobial effects. It aims to reveal the trends and main findings in the academic literature on this subject.Material and Methods: This article performs a detailed bibliometric analysis of the antimicrobial activity of chalcones using the Biblioshiny application from the Bibliometric package with the R program and the VOSviewer tool. The Scopus database was searched for 571 relevant articles published between 2014 and 2024. Results: India is the most important country, followed by Brazil and then China. The article “A Review: The Pharmacology of Isoliquiritigenin” by Peng et al. (2015) published in PHYTOTHER RES was the most contributing study with 222 citations. With 23 articles, JOURNAL OF MOLECULAR STRUCTURE is the most important journal and OSMANIA UNIVERSITY is the most important institution with 77 articles. Conclusion: 571 English-language publications on chalcones and antimicrobials were identified within the relevant time frame. The results were as follows: the average age of the articles was 5.18 years, and there were an average of 13.93 citations per document. Of the 2,447 authors, 13 were sole authors. International co-authorship accounted for 18.74% of all co-authored articles. According to the three-field graph, the top country is “Brazil,” the leading author parameter is “Bandeira Pn.,” and the keyword is “antimicrobial activity.”