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May 3, 2005CirculationOpen Access

Transgenic Rabbit Model for Human Troponin I–Based Hypertrophic Cardiomyopathy

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Population

Transgenic rabbit model for human troponin I-based hypertrophic cardiomyopathy

Comparison

Transgenic expression of cardiac troponin I… vs Normal cells/wild-type rabbits

Design

Preclinical

Authors

ASAtsushi SanbeIwate Medical UniversityJJJeanne JamesChildren's Hospital of WisconsinVTVolkan TuzcuIstanbul Medipol University

Discussion

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Implication

Indicates early remodeling in cTnI HCM model; leaves open human translation and clinical relevance.

Structured PICO

P
Population
Transgenic rabbit model for human troponin I-based hypertrophic cardiomyopathy
I
Intervention
Transgenic expression of cardiac troponin I (cTnI) inhibitory domain mutation arginine146-->glycine (cTnI(146Gly)) in the rabbit ventricle
C
Comparator
Normal cells/wild-type rabbits
O
Outcome
Cardiac mechanics, morphology, and repolarization phase (force-pCa2+ curves, cardiomyocyte disarray, fibrosis, connexin43 organization, twitch relaxation, [Ca]i transients, QT(max) intervals)surrogate

A transgenic rabbit model of human cTnI(146Gly) hypertrophic cardiomyopathy demonstrates early pathological changes in cardiac mechanics and repolarization before obvious functional decline.

Cite This Study

Sanbe et al. (2005) studied this question.

synapsesocial.com/papers/6a1ed460ce3e167bb87e81fehttps://doi.org/10.1161/01.cir.0000164234.24957.75
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Transgenic Modeling of a Cardiac Troponin I Mutation Linked to Familial Hypertrophic Cardiomyopathy2000 · 152 citations
  2. 2Myofilament Calcium Sensitivity and Cardiac Disease2002 · 58 citations
  3. 3Simvastatin Induces Regression of Cardiac Hypertrophy and Fibrosis and Improves Cardiac Function in a Transgenic Rabbit Model of Human Hypertrophic Cardiomyopathy2001 · 341 citations
  4. 4Abnormal Cardiac Structure and Function in Mice Expressing Nonphosphorylatable Cardiac Regulatory Myosin Light Chain 21999 · 124 citations
  5. 5Essential role of troponin I in the positive inotropic response to isoprenaline in mouse hearts contracting auxotonically2004 · 66 citations