What does this research mean for the field?

Myocardial contraction activation is a highly cooperative process in which initial myosin crossbridge binding to thin filaments recruits additional crossbridges and increases calcium binding to troponin C, rather than relying solely on a simple calcium-dependent switch. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

May 27, 2004Circulation ResearchOpen Access

Myosin Crossbridge Activation of Cardiac Thin Filaments

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Authors

RMRichard L. MossUniversity of Vermont MRMaria V. RazumovaUniversity of Washington DFDaniel P. FitzsimonsUniversity of Idaho

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Implication

May underlie contractile dysfunction in cardiomyopathies; extends molecular models but leaves open targeted interventions.

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Key points are not available for this paper at this time.

Cite This Study

Moss et al. (2004) studied this question.

synapsesocial.com/papers/6a1ed460ce3e167bb87e8200 https://doi.org/10.1161/01.res.0000127125.61647.4f

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Myosin Crossbridge Activation of Cardiac Thin Filaments

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Implication

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Cite This Study

Myosin Crossbridge Activation of Cardiac Thin Filaments

Discussion

Member takes

Implication

Key Points

Cite This Study

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