What does this research mean for the field?

Mutations in human cardiac troponin subunits lead to functional consequences that serve as primary mechanisms in the pathogenesis of dilated, hypertrophic, and restrictive cardiomyopathies. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 2004The Japanese Journal of PhysiologyOpen Access

Inherited Cardiomyopathies as a Troponin Disease

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Population

Patients with inherited cardiomyopathies associated with mutations in human cardiac troponin subunits

Design

Review

Authors

KHKatsumasa HaradaUniversity of Tsukuba SMSachio MorimotoFukuoka International University

Discussion

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Implication

May inform genetic panels for inherited cardiomyopathies; extends sarcomeric mutation catalogs for mechanistic research.

Structured PICO

Population

Patients with inherited cardiomyopathies (dilated, hypertrophic, and restrictive forms) associated with mutations in human cardiac troponin subunits

Outcome

Functional consequences and primary mechanisms for the pathogenesis of different types of cardiomyopathy

This review highlights the critical role of over 60 identified mutations in cardiac troponin subunits in the pathogenesis of various inherited cardiomyopathies.

Cite This Study

Harada et al. (2004) studied this question.

synapsesocial.com/papers/6a1ed460ce3e167bb87e8202 https://doi.org/10.2170/jjphysiol.54.307

Topics

Hypertrophic cardiomyopathy

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Inherited Cardiomyopathies as a Troponin Disease

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Inherited Cardiomyopathies as a Troponin Disease

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Topics

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