Key result
Rheumatoid arthritis patients without known cardiovascular disease had significantly higher extracellular volume (30.3% vs 27.9%, p<0.001) and impaired myocardial strain compared to matched controls.
Why the study?
Can CMR T1 mapping detect subclinical diffuse myocardial fibrosis and is it associated with impaired myocardial strain in patients with rheumatoid arthritis?
Cross-Sectional (n=78)
No
Can CMR T1 mapping detect subclinical diffuse myocardial fibrosis and is it associated with impaired myocardial strain in patients with rheumatoid arthritis?
Absolute Event Rate: 30.3% vs 27.9%
p-value: p=< 0.001
CMR T1 mapping may be a useful non-invasive tool to detect subclinical diffuse myocardial fibrosis and assess its association with myocardial strain in rheumatoid arthritis.
Hypothesis-generating for CMR detection of subclinical fibrosis in RA; prospective validation needed before clinical adoption.
Background Rheumatoid arthritis (RA) is a chronic autoimmune disease of the joints, with frequent extra-articular complications including cardiovascular disease and cardiac fibrosis from multiple causes. Diffuse myocardial fibrosis can be detected non-invasively by extracellular volume (ECV) mapping based on preand postcontrast T1 measurements using cardiovascular magnetic resonance (CMR). We therefore hypothesized that CMR T1 mapping can detect subclinical diffuse myocardial fibrosis in patients with RA.
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Ntusi et al. (2014) conducted a cross-sectional in Rheumatoid arthritis (n=78). Rheumatoid arthritis vs. Matched controls was evaluated on Extracellular volume (ECV) (p=< 0.001). Rheumatoid arthritis patients without known cardiovascular disease had significantly higher extracellular volume (30.3% vs 27.9%, p<0.001) and impaired myocardial strain compared to matched controls.
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