Each 1-SD increase in day-to-day variability of home systolic blood pressure was significantly associated with future cognitive decline (OR 1.51; P=0.02).
Cohort (n=485)
Does home blood pressure measurement and its day-to-day variability predict cognitive decline better than conventional blood pressure in adults without baseline cognitive impairment?
Day-to-day variability in home systolic blood pressure is a significant predictor of future cognitive decline, outperforming conventional blood pressure measurements.
Odds Ratio: 1.51
p-value: p=0.02
Although an association between high blood pressure and cognitive decline has been reported, no studies have investigated the association between home blood pressure and cognitive decline. Home blood pressure measurements can also provide day-to-day blood pressure variability calculated as the within-participant SD. The objectives of this prospective study were to clarify whether home blood pressure has a stronger predictive power for cognitive decline than conventional blood pressure and to compare the predictive power of the averaged home blood pressure with day-to-day home blood pressure variability for cognitive decline. Of 485 participants (mean age, 63 years) who did not have cognitive decline (defined as Mini-Mental State Examination score, <24) initially, 46 developed cognitive decline after a median follow-up of 7.8 years. Each 1-SD increase in the home systolic blood pressure value showed a significant association with cognitive decline (odds ratio, 1.48; P=0.03). However, conventional systolic blood pressure was not significantly associated with cognitive decline (odds ratio, 1.24; P=0.2). The day-to-day variability in systolic blood pressure was significantly associated with cognitive decline after including home systolic blood pressure in the same model (odds ratio, 1.51; P=0.02), whereas the odds ratio of home systolic blood pressure remained positive, but it was not significant. Home blood pressure measurements can be useful for predicting future cognitive decline because they can provide information not only on blood pressure values but also on day-to-day blood pressure variability.
Matsumoto et al. (Tue,) conducted a cohort in Cognitive decline (n=485). Day-to-day variability in home systolic blood pressure vs. Conventional systolic blood pressure was evaluated on Cognitive decline (OR 1.51, p=0.02). Each 1-SD increase in day-to-day variability of home systolic blood pressure was significantly associated with future cognitive decline (OR 1.51; P=0.02).