What does this research mean for the field?

Ryanodine receptors (RyRs) and myosin light chain kinase (MLCK) mediate an essential calcium signaling cascade required for myosin thick filament assembly during myofibrillogenesis. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

June 15, 1998The Journal of Cell BiologyOpen Access

A Calcium Signaling Cascade Essential for Myosin Thick Filament Assembly in Xenopus Myocytes

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Population

Xenopus myocytes

Design

Preclinical

Authors

MFMichael B. FerrariBeth Israel Deaconess Medical Center KRKatharina RibbeckIIT@MIT DHDonald J. HaglerPediatric Cardiology

Discussion

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Implication

Supports essential developmental roles of RyR and MLCK in striated muscle; hypothesis-generating for sarcomeric disorders, should not change practice.

Structured PICO

Population

Xenopus myocytes

Intervention

Blockade of Ca2+ release from the ryanodine receptor (RyR) activated Ca2+ store, or inhibition of an embryonic Ca2+/calmodulin-dependent myosin light chain kinase (MLCK)

Outcome

Myosin thick filament (A band) assembly and sarcomeric organizationsurrogate

RyRs and MLCK have essential developmental roles during the construction of the contractile apparatus in striated muscle.

Cite This Study

Ferrari et al. (1998) studied this question.

synapsesocial.com/papers/6a1ee554b89226e3ad88c2cd https://doi.org/10.1083/jcb.141.6.1349

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Implication

Supports essential developmental roles of RyR and MLCK in striated muscle; hypothesis-generating for sarcomeric disorders, should not change practice.

A Calcium Signaling Cascade Essential for Myosin Thick Filament Assembly in Xenopus Myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A Calcium Signaling Cascade Essential for Myosin Thick Filament Assembly in Xenopus Myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider