Key result
In vitro tension-inflation testing combined with X-ray microtomography successfully visualized early arterial dissection, suggesting high shear stress at the crack tip triggers propagation.
Why the study?
Few studies have investigated the initiation sequence of arterial dissection due to difficulties in monitoring how an intimal tear propagates into a dissection.
A novel in vitro X-ray microtomography method allows for the observation of arterial dissection mechanisms, highlighting high shear stress at the crack tip as a potential propagation trigger.
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Hypothesis-generating for arterial dissection mechanisms; leaves open in vivo validation before clinical translation.
Brunet et al. (2020) studied Arterial dissection (n=2). Tension-inflation test with X-ray microtomography was evaluated on Notch morphology and crack propagation. In vitro tension-inflation testing combined with X-ray microtomography successfully visualized early arterial dissection, suggesting high shear stress at the crack tip triggers propagation.
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