Key result
Simulated aortic dissections occur at ~79 kPa, with sex, location, and plaque altering medial strength.
Why the study?
Physical factors involved in the initiation and propagation of aortic dissections in human aortas were not well characterized.
Aortic dissection in human autopsy aortas requires extremely high nonphysiological pressures, suggesting spontaneous dissection is unlikely without connective tissue disorders or surgical procedures.
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Dissections require nonphysiological pressures in autopsy aortas; leaves open spontaneous mechanisms in connective tissue disorders and needs in vivo validation.
Tiessen et al. (1993) studied Aortic dissection (n=21). Infusion of dyed isotonic saline into the media was evaluated on Mean pressure for dissection. Simulated dissections in human autopsy aortas occurred at a nonphysiological mean pressure of 79 kPa, with sex, location, and atherosclerotic plaque significantly affecting medial strength (p<0.05).
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