Key result
Systemic hypoxia and adenosine infusion evoked increases in venous-arterial nitric oxide difference, which were abolished by NOS inhibitor l-NAME and adenosine A1 receptor antagonist DPCPX.
Muscle vasodilatation during systemic hypoxia is partly mediated by adenosine acting at endothelial A1 receptors to stimulate NO synthesis and release.
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Extends mechanistic evidence for adenosine A1-NO mediation of hypoxic vasodilatation in animals; leaves open human translation.
Ray et al. (2005) studied Hypoxic vasodilatation in skeletal muscle (n=14). Systemic hypoxia and adenosine infusion vs. l-NAME and DPCPX was evaluated on Venous-arterial [NO] difference ([NO](v-a)). Systemic hypoxia and adenosine infusion evoked increases in venous-arterial nitric oxide difference, which were abolished by NOS inhibitor l-NAME and adenosine A1 receptor antagonist DPCPX.
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