Key result
Spinal cord stimulation significantly improved quality of life and reduced the frequency of angina pectoris attacks from more than 4 times a day to 1-2 times a week (p<0.001).
Why the study?
Spinal cord stimulation improves quality of life and reduces angina in refractory angina pectoris, but the effect warranted evaluation in a cohort using a multidisciplinary selection approach.
Does spinal cord stimulation improve quality of life and reduce angina frequency in patients with refractory angina pectoris?
Observational (n=87)
Open-label
No
Does spinal cord stimulation improve quality of life and reduce angina frequency in patients with refractory angina pectoris?
Spinal cord stimulation significantly improves quality of life and reduces angina frequency in patients with refractory angina pectoris over 1 year of follow-up.
Answers are grounded in this paper and cite their sources.
May support SCS for refractory angina; leaves open confirmation in randomized trials.
AIMS: Spinal cord stimulation (SCS) is a treatment for patients with refractory angina pectoris (RAP) who remain symptomatic despite optimal medical therapy and without revascularisation options. Previous studies have shown that SCS improves the quality of life in this patient group and reduces the severity of the angina pectoris. The aim of this prospective, single-arm observational study is to show this effect in a single-centre cohort using a multidisciplinary team approach to the selection process, with a follow-up period of 1 year. METHODS AND RESULTS: Between July 2010 and March 2017, 87 patients with RAP referred to our centre received SCS. The Seattle Angina Questionnaire (SAQ) and RAND 36-Item Health Survey (RAND-36) were completed at baseline, prior to implantation, and 1 year post-implantation. After 1 year of follow-up there was a statistically significant decrease in the frequency of angina pectoris attacks from more than 4 times a day to 1-2 times a week (p < 0.001). The SAQ showed statistically significant improvement in four of the five dimensions: physical limitation (p < 0.001), angina frequency (p < 0.001), angina stability (p < 0.001) and quality of life (p < 0.001). The RAND-36 showed statistically significant improvement in all nine dimensions: physical functioning (p = 0.001), role/physical (p < 0.001), social functioning (p = 0.03), role/emotional (p < 0.05), bodily pain (p < 0.001), general health (p < 0.001), vitality (p < 0.001), mental health (p = 0.02) and health change (p < 0.001). CONCLUSION: This study showed a significant improvement in quality of life and reduction of angina pectoris severity after 1 year of follow-up in patients treated with SCS for RAP.
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Vervaat et al. (2020) conducted an observational in Refractory angina pectoris (n=87). Spinal cord stimulation vs. Baseline was evaluated on Quality of life and frequency of angina symptoms (p=<0.001). Spinal cord stimulation significantly improved quality of life and reduced the frequency of angina pectoris attacks from more than 4 times a day to 1-2 times a week (p<0.001).
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