Key result
TNF-alpha treatment augmented the reduction of cell-surface HLA class I and EGF-R molecules by upregulating E3/19K protein and mRNA, suggesting a mechanism for adenovirus to escape immunosurveillance.
Why the study?
Does TNF-alpha stimulate the expression of adenovirus early region 3 proteins in human cells?
Population
Human cell line 293 transfected with the entire E3 region of adenovirus 2 (Ad2) and infection experiments
Comparison
Treatment with cytokines tumor necrosis factor… vs null
Design
Preclinical
Authors
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TNF-alpha may aid adenovirus immune evasion in human cells; leaves open relevance to clinical infection or therapy.
Does TNF-alpha stimulate the expression of adenovirus early region 3 proteins in human cells?
TNF-alpha upregulates adenovirus E3 proteins, providing evidence that the virus utilizes host immune mediators to escape immunosurveillance.
Körner et al. (1992) studied Adenovirus infection (in vitro model). TNF-alpha and IFN-gamma vs. Untreated/mock-treated cells was evaluated on Cell-surface expression of HLA class I and EGF-R, and E3/19K protein synthesis. TNF-alpha treatment augmented the reduction of cell-surface HLA class I and EGF-R molecules by upregulating E3/19K protein and mRNA, suggesting a mechanism for adenovirus to escape immunosurveillance.
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