Key result
Polarization-resolved microscopy demonstrated that high molecular actin ordering during sarcomere maturation occurs independently of muscle myosin motor activity in Drosophila.
Polarization-resolved microscopy reveals that while myosin motors are required for early myofibril assembly, the high-order organization of actin during sarcomere maturation occurs independently of muscle myosin motor activity.
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Findings in Drosophila warrant caution before mammalian extrapolation; leaves open myosin dependence of actin ordering in vertebrate sarcomeres.
Loison et al. (2018) studied Sarcomere maturation. Genetic manipulation of myosin (sqh, zip, Mhc) vs. Wild-type Drosophila was evaluated on Molecular actin order (angular distribution width, C). Polarization-resolved microscopy demonstrated that high molecular actin ordering during sarcomere maturation occurs independently of muscle myosin motor activity in Drosophila.
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