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It has been proposed that the beneficial effects of training on motor function can be enhanced by stimulation of alpha-adrenergic mechanisms. Consistent with this view, a single oral dose of the selective norepinephrine reuptake inhibitor reboxetine was found to enhance motor skill acquisition (rapid elbow flexion) and corticomotor excitability tested with transcranial magnetic stimulation in the absence of effects on basal motor performance. Therefore, alpha-adrenergic mechanisms could possibly be manipulated to magnify training effects in neurorehabilitation.
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Plewnia et al. (2004) studied this question.
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