What question did this study set out to answer?

To evaluate whether C-peptide replacement therapy improves sensory nerve function in patients with type 1 diabetes and peripheral neuropathy.

December 27, 2006Diabetes CareOpen Access

C-Peptide Replacement Therapy and Sensory Nerve Function in Type 1 Diabetic Neuropathy

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Authors

KEKarin EkbergAsarina Pharma (Sweden)TBTom BrismarKarolinska University Hospital BJBo‐Lennart JohanssonUppsala University

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Implication

Randomized double-blind trial demonstrates improved sensory nerve function in type 1 diabetic neuropathy, indicating therapeutic potential for early-stage peripheral nerve damage.

Key Points

To evaluate whether C-peptide replacement therapy improves sensory nerve function in patients with type 1 diabetes and peripheral neuropathy.
Exploratory, double-blind, randomized, placebo-controlled trial conducted across five centers in Sweden.
139 patients completed 6 months of treatment with subcutaneous C-peptide at a replacement dose (1.5 mg/day), a high dose (4.5 mg/day), or placebo.
Neurological impairment assessment (NIA score) and neurophysiological measurements, including sensory nerve conduction velocity (SCV) and vibration perception, were evaluated at baseline and after 6 months.
Sensory nerve conduction velocity (SCV) improved within both C-peptide arms (P < 0.007), and significantly more C-peptide-treated patients achieved an SCV peak potential increase >1.0 m/s compared with placebo (P < 0.03).
In patients with less advanced baseline impairment (SCV < 2.5 SD below normal, n = 70), SCV improved by 1.0 m/s compared with placebo (P < 0.014).
Neurological impairment score and vibration perception improved significantly within C-peptide-treated groups (P < 0.011 and P < 0.002, respectively), while A1C levels (7.6 ± 0.1% at baseline) decreased slightly and similarly across all groups.

Cite This Study

Ekberg et al. (2006) studied this question.

synapsesocial.com/papers/6a1ef57816ec2d13766b5873 https://doi.org/10.2337/dc06-1274

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Implication

Randomized double-blind trial demonstrates improved sensory nerve function in type 1 diabetic neuropathy, indicating therapeutic potential for early-stage peripheral nerve damage.

C-Peptide Replacement Therapy and Sensory Nerve Function in Type 1 Diabetic Neuropathy

Discussion

Member takes

Implication

Key Points

Cite This Study

C-Peptide Replacement Therapy and Sensory Nerve Function in Type 1 Diabetic Neuropathy

Discussion

Member takes

Implication

Key Points

Cite This Study

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