February 12, 1999FEBS Letters

Transgenic UCP1 in white adipocytes modulates mitochondrial membrane potential

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Why the study?

Does ectopic UCP1 expression in white adipocytes decrease mitochondrial membrane potential in mice?

Population

aP2-Ucp transgenic mice expressing ectopic uncoupling protein 1 in white fat

Comparison

Ectopic UCP1 expression vs Non-transgenic mice

Design

Preclinical

Authors

FBFilip BaumrukCzech Academy of Sciences PFPavel FlachsCzech Academy of Sciences MHMilada HorákováCzech Academy of Sciences

Discussion

Member takes

Implication

Supports anti-obesity potential of white adipocyte uncoupling; leaves open clinical translation from this mouse model.

Structured PICO

Does ectopic UCP1 expression in white adipocytes decrease mitochondrial membrane potential in mice?

Population

aP2-Ucp transgenic mice expressing ectopic uncoupling protein 1 (UCP1) in white fat (adipocytes isolated from gonadal fat)

Intervention

Ectopic UCP1 expression (approximately 0.8 mol UCP1/mol respiratory chain)

Comparator

Non-transgenic mice

Outcome

Mitochondrial membrane potential (delta psi(m)) estimated by flow cytometrysurrogate

Ectopic UCP1 expression in white adipocytes decreases mitochondrial membrane potential, supporting the hypothesis that mitochondrial uncoupling in white fat may prevent obesity.

Cite This Study

Baumruk et al. (1999) studied this question.

synapsesocial.com/papers/6a1ef80d1fd398cbed6b54e2 https://doi.org/10.1016/s0014-5793(99)00053-8

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Transgenic UCP1 in white adipocytes modulates mitochondrial membrane potential

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Transgenic UCP1 in white adipocytes modulates mitochondrial membrane potential

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider