Key result
Upper respiratory illness induced by Coxsackie A-21 virus increased total protein and γ A globulin in nasal secretions, but specific antibody titers remained negligible for up to 17 days.
Why the study?
How does upper respiratory illness induced by Coxsackie A-21 virus alter the protein composition of nasal secretions in initially antibody-free volunteers?
Observational
How does upper respiratory illness induced by Coxsackie A-21 virus alter the protein composition of nasal secretions in initially antibody-free volunteers?
Enhanced excretion of γ A globulin in nasal secretion during Coxsackie A-21 infection does not appear to contribute significantly to early clinical recovery in initially antibody-free individuals.
Nasal γA rise during primary Coxsackie A-21 infection may not drive early recovery in seronegative hosts; leaves open innate mechanisms of viral clearance.
During the latter portion of upper respiratory illness induced with Coxsackie A-21 virus, there was a rise in total protein concentration and an increase in the frequency with which several plasma proteins were identified in nasal secretions. These changes in protein were independent of the presence of guaiac positive material in the nasal secretion specimens. Concentrations of γ A globulin before and during infection were higher in nasal secretion, in relation to the total protein, than are found in plasma, but antibody titers against Coxsackie A-21 in these secretions were negligible for up to 17 days following inoculation. The enhanced excretion of γ A globulin in nasal secretion during infection, therefore, probably did not contribute significantly to the clinical recovery of these initially antibody-free volunteers.
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Rossen et al. (1965) conducted an observational in Upper respiratory illness. Coxsackie A-21 virus infection vs. Pre-infection baseline was evaluated on Protein composition and antibody titers in nasal secretions. Upper respiratory illness induced by Coxsackie A-21 virus increased total protein and γ A globulin in nasal secretions, but specific antibody titers remained negligible for up to 17 days.
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