Key result
In adults without prior comorbidities, depression increased the 10-year risk of a first physical illness in females (HR 1.16; 95% CI 1.07-1.26) and males (HR 1.20; 95% CI 1.07-1.36).
Why the study?
It was unclear whether depression is associated with the development of physical illness and multimorbidity after controlling for socioeconomic, behavioral, and other potential confounders.
Does depression increase the risk of developing physical illness and multimorbidity in adults with no prior comorbidities?
Cohort (n=29,838)
Does depression increase the risk of developing physical illness and multimorbidity in adults with no prior comorbidities?
Hazard Ratio: 1.16 (95% CI 1.07–1.26)
Depression is an independent risk factor for the development of incident physical illness and multimorbidity in previously healthy adults.
No takes yet. Share an insight, caveat, or question.
Depression may warrant inclusion in risk assessment for healthy adults; leaves open whether treatment prevents incident physical illness.
Li et al. (2020) conducted a cohort in No prior comorbidity (n=29,838). Depression vs. No depression was evaluated on Development of a first physical illness (1 of 15 common chronic conditions) (HR 1.16, 95% CI 1.07 to 1.26). In adults without prior comorbidities, depression increased the 10-year risk of a first physical illness in females (HR 1.16; 95% CI 1.07-1.26) and males (HR 1.20; 95% CI 1.07-1.36).
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