Key result
A review and simulation study of 12 late-phase insulin clinical trials provides guidance on implementing crossover designs in diabetes studies, specifically addressing carryover effects and washout periods.
Population
12 crossover late-phase insulin clinical trials (used for data mining and simulation)
Design
Other
Authors
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May inform crossover trial design in diabetes; leaves open prospective validation of washout recommendations.
This methodological paper provides guidance on implementing crossover designs in late-phase diabetes trials, particularly regarding carryover effects and washout periods.
Wang et al. (2016) conducted a review in Diabetes. Crossover design was evaluated. A review and simulation study of 12 late-phase insulin clinical trials provides guidance on implementing crossover designs in diabetes studies, specifically addressing carryover effects and washout periods.
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