June 1, 1998Journal of Cell Science
Characterizing titin’s I-band Ig domain region as an entropic spring
Population
Rat psoas myofibrils
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Titin compliance data may refine sarcomere tension models; leaves open human cardiac translation.
Structured PICO
P
Population
Rat psoas myofibrils
I
Intervention
Measurement of elastic properties of the N-terminal I-band Ig region using immunofluorescence/immunoelectron microscopy and myofibril mechanics
O
Outcome
Elastic properties (extension behavior, force-extension curve, persistence length) of the N-terminal I-band Ig region of titinsurrogate
The poly-Ig regions of titin act as compliant entropic springs that determine the minute levels of passive tension at low extensions of a muscle fiber.
Cite This Study
Linke et al. (1998) studied this question.