Key result
In rat cardiac muscle, 80% of myosin heads transferred to the thin filament during maximum isometric contraction at pCa 4.4, with disproportionately large transfer at low calcium concentrations.
In rat cardiac muscle, a significant fraction of myosin heads transfer to thin filaments at low calcium concentrations without producing tension.
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Findings in rat myocardium remain preclinical; leaves open whether low-calcium myosin transfer applies to human cardiac muscle.
Matsubara et al. (1989) studied this question. Calcium concentration was evaluated on Transfer of myosin heads from thick to thin filaments. In rat cardiac muscle, 80% of myosin heads transferred to the thin filament during maximum isometric contraction at pCa 4.4, with disproportionately large transfer at low calcium concentrations.
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