Key result
Maximum activation of chemically skinned mouse toe muscle at pCa 4.4 decreased the 1,0 spacing of the hexagonal myofilament lattice from 40.8 nm to 38.4 nm.
Absolute Event Rate: 38.4% vs 40.8%
The study supports the view that lattice shrinkage during muscle contraction is driven by cross-bridges displaced from their optimum lateral positions.
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Calcium-dependent lattice compression in skinned mouse muscle leaves open its role in human cardiac force generation.
Matsubara et al. (1985) studied this question. Calcium activation vs. Relaxed state was evaluated on 1,0 spacing of the hexagonal myofilament lattice at a sarcomere length of 2.5 micron (nm). Maximum activation of chemically skinned mouse toe muscle at pCa 4.4 decreased the 1,0 spacing of the hexagonal myofilament lattice from 40.8 nm to 38.4 nm.
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