Key result
Co-activation of the exercise pressor reflex and hypoxia-induced chemoreflex produced hyper-additive increases in blood pressure and heart rate, and hypo-additive peripheral haemodynamics.
Why the study?
Although the exercise pressor reflex and chemoreflex have recognized sympathoexcitatory effects, the cardiovascular implications of their interaction remained elusive.
Does the interaction between the exercise pressor reflex and chemoreflex alter cardiovascular responses during exercise in healthy humans?
Does the interaction between the exercise pressor reflex and chemoreflex alter cardiovascular responses during exercise in healthy humans?
The co-activation of the exercise pressor reflex and hypoxia-induced chemoreflex during exercise synergistically increases blood pressure and heart rate while restricting blood flow to contracting muscles.
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May heighten pressor responses during hypoxic exercise; leaves open relevance to patients with augmented reflexes.
Wan et al. (2020) studied Healthy (n=11). Lumbar intrathecal fentanyl and altered inspired gases (hypoxia or hypercapnia) vs. Without fentanyl and ambient air was evaluated on Cardiovascular response (mean arterial pressure, heart rate, leg blood flow, leg vascular conductance). Co-activation of the exercise pressor reflex and hypoxia-induced chemoreflex produced hyper-additive increases in blood pressure and heart rate, and hypo-additive peripheral haemodynamics.
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