Infection with Chlamydia pneumoniae as a cause of coronary heart disease: the hypothesis is still untested#

December 4, 2014Pathogens and DiseaseOpen Access

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Key Points

To review and evaluate the hypothesis that Chlamydia pneumoniae infection directly contributes to the pathogenesis of coronary heart disease.
Synthesized available clinical and microbiological literature examining the association between Chlamydia pneumoniae and cardiovascular pathology.
Evaluated pathological criteria and epidemiological evidence supporting a potential causal relationship.
Highlights an absence of definitive clinical trial data establishing a causal link between Chlamydia pneumoniae and coronary atherogenesis.
Concludes that the proposed causal mechanism remains an untested hypothesis requiring rigorous prospective validation.

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Review evaluates coronary heart disease risk from Chlamydia pneumoniae infection in humans, highlighting that a causal link remains unproven.

Review of the possible role of Chlamydia pneumoniae infection in the pathogenesis of heart disease.

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Grayston et al. (2014) studied this question.

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