Key result
Aortic unfolding measured on non-contrast cardiac CT increased with advancing age and was associated with male sex, body surface area, and cardiovascular risk factors.
Why the study?
Factors influencing aortic unfolding on coronary artery calcium scans and its normal reference limits were not established.
Cross-Sectional (n=924)
No
Aortic unfolding measured on routine non-contrast cardiac CT increases with age, male sex, and body surface area, and is independently associated with cardiovascular risk factors such as CAC score and left ventricular hypertrophy.
Answers are grounded in this paper and cite their sources.
Aortic unfolding on routine non-contrast CT may mark vascular aging; leaves open its incremental prognostic value beyond CAC or LVH.
Purpose: This study aimed to assess the factors influencing aortic unfolding (AU) defined by aortic width on coronary artery calcium (CAC) scan and determine the normal limits for AU. Materials and Methods: In this retrospective study, we measured AU in 924 asymptomatic subjects who underwent CAC scanning during routine health screening from June 2015 to June 2018. Multivariate regression analysis was used to evaluate the factors influencing AU. After the exclusion of subjects with risk factors associated with AU, 283 subjects were included in the analysis of normal values of AU. Mean AU, standard deviation, and upper normal limit were calculated. Results: Sex, age, CAC score, body mass index, body surface area, hypertension, left ventricular hypertrophy, plasma creatinine, and smoking were significantly associated with AU. The mean AU was 102.2 ± 12.8 mm for men and 93.1 ± 10.7 mm for women. AU increased with advancing age (9.6 mm per decade). Conclusion: AU determined from a single measurement on CAC scans was associated with cardiovascular risk factors. The normal limits of AU were defined by age, sex, and body surface area in low-risk subjects in this study.
No takes yet. Share an insight, caveat, or question.
Lee et al. (2021) conducted a cross-sectional in Asymptomatic subjects undergoing routine health screening (n=924). Advancing age and cardiovascular risk factors was evaluated on Aortic unfolding (AU) width (9.6 mm per decade, p=<0.001). Aortic unfolding measured on non-contrast cardiac CT increased with advancing age and was associated with male sex, body surface area, and cardiovascular risk factors.
Synapse has enriched 10 related papers. Consider them for comparative context: