January 1, 2008Emotion
Investigating models of affect: Relationships among EEG alpha asymmetry, depression, and anxiety.
Key result
Anxiety was associated with greater right frontal lateralization, whereas depression/comorbidity showed symmetrical frontal activity, compared to left frontal lateralization in healthy controls.
Population
428 participants categorized on the basis of negative mood and alpha EEG
Design
Cross-sectional
Authors
Discussion
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Implication
Supports distinct frontal EEG patterns in anxiety versus depression; hypothesis-generating for biomarkers, needs prospective validation before clinical use.
Study Design
Type
Cross-Sectional (n=428)
Structured PICO
P
Population
428 participants evaluated to investigate the relationships among nonclinical depression/anxiety and lateralized frontal/parietotemporal activity.
O
Outcome
Relationships among nonclinical depression/anxiety and lateralized frontal/parietotemporal activitysurrogate
Findings support predictions for frontal but not posterior regions regarding the approach-withdrawal and valence-arousal models of depression and anxiety.
Limitations
- Grouping on the basis of EEG may not be reciprocally predictive of negative mood groupings, suggesting involvement of additional factors.
Cite This Study
Mathersul et al. (2008) conducted a cross-sectional in Nonclinical depression and anxiety (n=428). Nonclinical depression and anxiety vs. Healthy controls was evaluated on Lateralized frontal and parietotemporal activity (EEG alpha asymmetry). Anxiety was associated with greater right frontal lateralization, whereas depression/comorbidity showed symmetrical frontal activity, compared to left frontal lateralization in healthy controls.