Key result
Two patients with effusive constrictive pericarditis were managed successfully with steroids and colchicine, obviating the need for surgery.
Why the study?
Can medical therapy (steroids or colchicine) successfully treat effusive constrictive pericarditis and obviate the need for surgery?
Case Report (n=2)
Can medical therapy (steroids or colchicine) successfully treat effusive constrictive pericarditis and obviate the need for surgery?
Medical therapy with steroids or colchicine may be an effective alternative to surgical pericardial stripping in some patients with effusive constrictive pericarditis.
Hypothesis-generating for steroids/colchicine in effusive constrictive pericarditis; prospective trials needed before clinical adoption.
Effusive constrictive pericarditis (ECP) is a relatively infrequent pericardial condition. The diagnosis is typically made when symptoms and right heart pressure elevation persist despite drainage of pericardial effusion. Visceral and parietal pericardial stripping is an extensive procedure with significant morbidity and mortality but is widely considered the only effective treatment. Recent studies suggest that up to 10% of constriction may be reversible, and a newer series has reported spontaneous complete resolution of symptoms in a subset of ECP patients. In this review, the authors describe 2 patients with ECP who were managed successfully with steroids and colchicine, respectively, thus obviating the need for surgery. The authors also review the current understanding of this reversible pericardial pathology and explore the possible role for colchicine in treating this condition.
No takes yet. Share an insight, caveat, or question.
Garg et al. (2009) conducted a case report in Effusive constrictive pericarditis (n=2). Steroids and colchicine was evaluated on Resolution of symptoms and avoidance of surgery. Two patients with effusive constrictive pericarditis were managed successfully with steroids and colchicine, obviating the need for surgery.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: